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RESEARCH PRODUCT

Non-compact myocardium assessment by cardiac magnetic resonance: dependence on image analysis method

Maria Filomena SantarelliFrancesca MacaioneSalvatore NovoAlessia PepeAndrea BarisonLaura PistoiaVincenzo PositanoAntonella Meloni

subject

AdultMaleRadiology Nuclear Medicine and ImagingHeart VentriclesMagnetic Resonance Imaging Cine030204 cardiovascular system & hematology030218 nuclear medicine & medical imagingYoung Adult03 medical and health sciences0302 clinical medicineNuclear magnetic resonanceMagnetic resonance imagingNuclear Medicine and ImagingImage Processing Computer-AssistedmedicineHumansComputer-assisted image analysiComputer-assisted image analysis; Isolated noncompaction of the ventricular myocardium; Magnetic resonance imaging; Radiology; Nuclear Medicine and Imaging; Cardiology and Cardiovascular MedicineCardiac imagingAnalysis methodAgedReproducibilitymedicine.diagnostic_testbusiness.industryImage (category theory)Significant differenceReproducibility of ResultsMagnetic resonance imagingMiddle AgedReference StandardsComputer-assisted image analysisCardiac Imaging Techniquesmedicine.anatomical_structureVentricleIsolated noncompaction of the ventricular myocardiumFemalebusinessCardiac magnetic resonanceRadiologyCardiology and Cardiovascular Medicine

description

To compare image analysis methods for the assessment of left ventricle non-compaction from cardiac magnetic resonance (CMR) imaging. CMR images were analyzed in 20 patients and 10 normal subjects. A reference model of the MR signal was introduced and validated based on image data. Non-compact (NC) myocardium size and distribution were assessed by tracing a single, continuous contour delimiting trabeculated region (Jacquier) or by one-by-one selection of trabeculae (Grothoff). The global non-compact/compact (NC/C) ratio, the NC mass, and the segmental NC/C ratio were assessed. Results were compared with the reference model. A significant difference between Grothoff and Jacquier approaches in the estimation of NC/C ratio (32.08 ± 6.63 vs. 19.81 ± 5.72, p < 0.0001) and NC mass (26.59 ± 8.36 vs. 14.15 ± 5.73 g/m2, p < 0.0001) was found. The Grothoff approach better matches the expected signal distribution. Inter-observer reproducibility of both Grothoff and Jacquier methods was adequate (9.71 and 8.22%, respectively) with no significant difference between observers. Jacquier and Grothoff approaches are not interchangeable so that specific diagnostic thresholds should be used for different image analysis methods. Grothoff method seems to better capture the true extension of trabeculated tissue.

10.1007/s10554-018-1331-3http://hdl.handle.net/11577/3407282