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RESEARCH PRODUCT
Trisomy 12 and translocation (7;9) in an ovarian immature teratoma.
M. MartorellR. GilAntonio PellínC. Lopez GinesAntonio Llombart-boschF. Vilarsubject
endocrine systemmedicine.medical_specialtyPathologyAdolescentChromosomal translocationOvaryTrisomyBiologyTranslocation GeneticPathology and Forensic MedicinemedicineHumansYolk sacOvarian NeoplasmsChromosomes Human Pair 12CytogeneticsTeratomaObstetrics and Gynecologymedicine.diseaseMicroscopy Electronmedicine.anatomical_structureCell cultureKaryotypingImmunohistochemistryFemaleTrisomyChromosomes Human Pair 9Germ cellChromosomes Human Pair 7description
We report a case of an immature malignant ovarian teratoma with peritoneal implants diagnosed in an 18-year-old woman. The tumor was brought into remission after surgery (three laparotomies) and adjuvant chemotherapy. A residual peritoneal implant showed a mature epithelial and glial configuration. Histologically, the neuroectodermal component was dominant in the original tumor as well as in the metastases, being confirmed by immunohistochemistry and electron microscopy. A stem cell line has been obtained with cell culture, having a germ cell character and a yolk sac configuration. This line possessed a trisomy 12 and a translocation (7;9) similar to other chromosomal abnormalities described in immature teratomas of the testes and ovaries.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-09-01 | International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists |