6533b81ffe1ef96bd1277d81
RESEARCH PRODUCT
Expression of cell adhesion molecules in inflammatory myopathies.
Dominique S. TewsHans H. Goebelsubject
ImmunologyIntercellular Adhesion Molecule-1Lewis X AntigenVascular Cell Adhesion Molecule-1InflammationNectinReceptors Very Late AntigenE-selectinmedicineImmunology and AllergyHumansCell adhesionbiologyMyositisCell adhesion moleculeChemistrySoluble cell adhesion moleculesIntercellular Adhesion Molecule-1Lymphocyte Function-Associated Antigen-1Cell biologyNeurologycardiovascular systembiology.proteinNeural cell adhesion moleculeNeurology (clinical)medicine.symptomE-SelectinCell Adhesion Moleculesdescription
We examined the expression of cell adhesion molecules in 25 cases of inflammatory myopathies. Inflammatory myopathies showed upregulation of adhesion molecules. ICAM-1 was strongly expressed on endothelial cells as well as on fibroblasts and infiltrating leukocytes while the expression of VCAM-1, similar in its distribution, was much weaker. A few muscle fibers in polymyositis revealed sarcolemmal labeling for ICAM-1. ELAM-1 showed only weak expression on vessels. The inflammatory cellular infiltrates contained varying amounts of cells bearing the VCAM-1 ligand VLA-4 and the ELAM-1 ligand SLeX as well as large amounts of cells expressing LFA-1 alpha and beta, ligands of ICAM-1.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-06-01 | Journal of neuroimmunology |