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RESEARCH PRODUCT

Intracapillary HbO2 Saturation in Tumor Tissue of DS-Carcinosarcoma During Normoxia

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description

Investigations on solid tumor tissue have shown that O2 uptake by cancer cells depends largely on the supply conditions. The absence of sufficient neovascularization and a general rarefaction of the terminal vascular bed during tumor growth as well as reduced and inhcmogeneous blood flew due to vascular stasis in neoplastic tissue prevent normal functions of the terminal vascular bed. In some areas of the tumor circulating blood is not visible despite the intactness of vessels. Stasis occurs since lacuna-like, sinusoidal and cystiform blood vessels cannot be drained completely because ‘tissue-pressure’ due to continuous cell proliferation can prevent efficient circulation. Thrombosis follows and results in the occlusion of the vessels (Vaupel 1977). In addition, a considerable portion of tumor blood crosses arterio-venous shunts instead of circulating through the vascular network. Furthermore, the acidic environment in tumors may reduce red cell deformability during tumor passage.