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RESEARCH PRODUCT
Lymphoproliferative disorders in Sotos syndrome: Observation of two cases
Ottavio ZiinoMargherita L. CuztoMaria PiccioneGiovanni CorselloAldo CarcioneMario Giuffrèsubject
MalePathologymedicine.medical_specialtyLymphoproliferative disordersOvergrowth syndromeshemic and lymphatic diseasesmedicineHumansAbnormalities MultipleTumor typeSotos syndromeGrowth DisordersGenetics (clinical)Sotos syndromebusiness.industrySkullBrainSyndromemedicine.diseasePhenotypeLymphoproliferative DisordersLymphomaIncreased riskEl NiñoChild PreschoolLymphoblastic leukaemiabusinessdescription
Sotos syndrome is included among the overgrowth disorders, most of which have an increased risk of neoplasms. Sotos syndrome does not appear to be related to a specific tumor type, but rather to the development of solid tumors of ectodermal or mesodermal origin in general. We report on two Sotos syndrome patients who developed a non-Hodgkin lymphoma and an acute lymphoblastic leukaemia, respectively. Our experience suggests that there may exist a high frequency of lymphoproliferative disorders in Sotos syndrome, and points out the importance of a long-term follow-up of Sotos syndrome patients, to detect a possible neoplastic evolution. ©1996 Wiley-Liss, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-09-06 | American Journal of Medical Genetics |