6533b81ffe1ef96bd12785da
RESEARCH PRODUCT
Transformation of vulvar pseudolymphoma (lymphoma-like lesion) into a marginal zone B-cell lymphoma of labium majus.
John Jairo Gaona MoralesAna Pérez VallésFrancisco Gozalbo GrauJair Manuel Gutierrez HerreraConsuelo CalabuigJose Angel GarciaMiguel Martorellsubject
Pathologymedicine.medical_specialtyFollicular lymphomaLymphoplasmacytic LymphomaVulvaVulvaLesionPseudolymphomaimmune system diseaseshemic and lymphatic diseasesmedicinePseudolymphomaHumansAged 80 and overVulvar Neoplasmsbusiness.industryObstetrics and GynecologyLymphoma B-Cell Marginal ZoneMarginal zonemedicine.diseaseLymphomamedicine.anatomical_structureImmunologyMarginal zone B-cell lymphomaFemalemedicine.symptombusinessdescription
Lymphomas arising in the female genital tract are extremely uncommon. Diffuse large B-cell lymphoma and follicular lymphoma are the most common types. We describe the case of an 80-year-old woman with a recurrent lesion in the vulva initially diagnosed as a lymphoma-like lesion and evolving 7 years later into a marginal zone B-cell lymphoma (lymphoplasmacytic lymphoma). Diagnosis was based on the monotypic pattern of the plasmacellular component and the clonal rearrangement of immunoglobulin heavy chain genes. No previous cases of vulvar marginal zone B-cell lymphoma arising in the context of a persistent lymphoma-like lesion have been reported. We highlight the importance of differentiating benign from malignant lymphoid infiltrates in the vulva.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-08-01 | The journal of obstetrics and gynaecology research |