6533b81ffe1ef96bd127861c

RESEARCH PRODUCT

Endometrial Factor in Unexplained Infertility and Recurrent Implantation Failure

Xavier SantamariaCarlos SimónCarlos Simón

subject

Infertilitymedicine.medical_specialtyEndocrinology Diabetes and Metabolismmedicine.medical_treatmentmedia_common.quotation_subjectPsychological interventionFertilityFertilization in VitroEndometriumEndometriumEndocrinologyPregnancyPhysiology (medical)medicineHumansEmbryo ImplantationUnexplained infertilitymedia_commonPregnancyIn vitro fertilisationbusiness.industryObstetricsObstetrics and Gynecologymedicine.diseaseReview articleFertilitymedicine.anatomical_structureReproductive MedicineInfertilityFemalebusinessInfertility Female

description

AbstractUnexplained infertility (UI) and recurrent implantation failure (RIF) are diagnoses based on failed pregnancy attempts within current infertility treatment models. Both diagnoses are made when fertility is unexplained based on current diagnostic methods and has no clear cause; UI is diagnosed when testing is inconclusive, and RIF is diagnosed after three failed in vitro fertilization cycles. In both cases, interventions are often introduced without an understanding of the cause of the infertility, frequently leading to frustration for patients and caregivers. Here, we review evidence to support an influence of endometrial factor in patients given these poorly defined diagnoses and possible treatments targeting the endometrium to improve outcomes in these patients.

yearjournalcountryeditionlanguage
2021-08-24Seminars in Reproductive Medicine
https://doi.org/10.1055/s-0041-1735199