6533b81ffe1ef96bd1278770
RESEARCH PRODUCT
Immunohistochemistry of cholinergic receptors.
Hannsjörg Schrödersubject
EmbryologyNeuromuscular JunctionBiologyNeuromuscular junctionMicePostsynaptic potentialMuscarinic acetylcholine receptormedicineMuscarinic acetylcholine receptor M4AnimalsHumansReceptors CholinergicAcetylcholine receptorCerebral CortexAntibodies MonoclonalCell BiologyNeuromuscular DiseasesImmunohistochemistryRatsMicroscopy Electronmedicine.anatomical_structureNicotinic agonistCholinergicAnatomyNeuroscienceAcetylcholineDevelopmental Biologymedicine.drugdescription
Acetylcholine and its receptors are involved in a variety of important signal transduction processes. As shown here paradigmatically for the human neuromuscular junction and the cerebral cortex, acetylcholine receptors can be visualized immunohistochemically at the cellular and subcellular level under physiological and pathological conditions. At normal motor endplates nicotinic cholinoceptors are localized at the surface of the postsynaptic junctional folds. In myasthenic syndromes investigation of muscle biopsies enables the diagnosis of receptor deficiencies at the ultrastructural level. In normal cerebral cortex pyramidal neurons are equipped with both nicotinic and muscarinic acetylcholine receptors localized to postsynaptic densities. In neuropsychiatric diseases cholinoceptor expression can be monitored at the cellular level by quantititative assessment of immunolabeled cortical neurons.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-10-01 | Anatomy and embryology |