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RESEARCH PRODUCT
Triterpene Saponins from Cyclamen trocopteranthum
Ilkay Erdogan OrhanAnne Claire Mitaine-offerTomofumi MiyamotoMarie Aleth Lacaille-duboisGhezala Mihci-gaidiOlivier DuchampBilge SenerSüheyla ÖZbeyJean François Mirjoletsubject
Spectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyStereochemistryChemical structurePlant compositionPharmaceutical ScienceAnalytical ChemistryTerpeneTumor colonTriterpeneCell Line TumorDrug DiscoveryHumansCyclamenPharmacologychemistry.chemical_classificationbiologyChemistryOrganic ChemistryNuclear magnetic resonance spectroscopySaponinsbiology.organism_classificationTriterpenesComplementary and alternative medicineCarbohydrate SequenceMolecular MedicineCyclamenTwo-dimensional nuclear magnetic resonance spectroscopydescription
Two new triterpene saponins ( 1- 2) together with three known saponins, deglucocyclamin I ( 3), cyclamin ( 4), and mirabilin ( 5), were isolated from the tubers of Cyclamen trocopteranthum. They were elucidated as 3 beta- O-{4- O-[3-hydroxyl-3-methylglutaryl]- beta-D-xylopyranosyl-(1 --> 2)- beta-D-glucopyranosyl-(1 --> 4)-[ beta-D-glucopyranosyl-(1 --> 2)]- alpha-L-arabinopyranosyl}-16 alpha-hydroxy-13 beta,28-epoxy-oleanan-30-al ( 1) and 3 beta- O-{4- O-[3-hydroxyl-3-methylglutaryl]- beta-D-xylopyranosyl-(1 --> 2)-[ beta-D-glucopyranosyl-(1 --> 6)]- beta-D-glucopyranosyl-(1 --> 4)-[ beta-D-glucopyranosyl-(1 --> 2)]- alpha-L-arabinopyranosyl}-16 alpha-hydroxy-20,30-lactone-olean-12-ene ( 2). Their structures were characterized mainly by a combination of 1D- and 2D-NMR techniques ( (1)H- (1)H COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectroscopy. Saponins 1, 3, and 4 showed a weak cytotoxic activity when tested against HT-29 and HCT 116 tumor colon cancer cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-01 |