6533b81ffe1ef96bd127885e
RESEARCH PRODUCT
Response to: 'IL-23 expression and activation of autophagy in synovium and PBMCs of HLA-B27 positive patients with ankylosing spondylitis' by Neerinckx et al.
Francesco CicciaGiovanni TrioloRiccardo Alessandrosubject
Ankylosing spondylitisIL-23 Ankylosing Spondylitisbusiness.industryAnkylosing SpondylitisImmunologyATG5AutophagyInterleukinmedicine.diseasePeripheral blood mononuclear cellGeneral Biochemistry Genetics and Molecular BiologyRheumatologyIL-23ImmunologyIRGMmedicineInterleukin 23Immunology and AllergybusinessATG16L1description
We read with interest the study by Neerinckx et al 1 addressing the expression of interleukin (IL)-23p19 and of autophagy genes in the synovium and in the peripheral blood mononuclear cells of patients with ankylosing spondylitis (AS). Differently from our observation in the gut,2 the authors failed to demonstrate any significant increase by RT-PCR in the expression of synovium autophagy-related genes (ATG16L1, IRGM, MAP1LC3A, ATG5, HSPA8 and HSP90AA1) together with no significant overexpression of IL-23p19 compared with disease and healthy controls. We have previously demonstrated by immunohistochemistry that in the …
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-08-20 |