The immunoprotective and diagnostic potential of influenza virus haemagglutinin stalk domain for development of novel vaccine prototypes

6533b81ffe1ef96bd1278ad4

RESEARCH PRODUCT

The immunoprotective and diagnostic potential of influenza virus haemagglutinin stalk domain for development of novel vaccine prototypes

Anna Kiršteina

subject

Bioloģija Biology Molecular Biology Molekulārā bioloģija

description

Pret konservatīviem gripas vīrusa epitopiem mērķēta vakcīna varētu paplašināt inducēto imunitāti un novērst nepieciešamību pēc ikgadējas vakcīnas komponentu atjaunošanas. Lai noteiktu stalka specifisko imunitāti cūkkopības darbinieku pirms pandēmijas serumā, tika izmantots gripas vīrusa stalks. Uz VLP eksponēts lineārs stalks izsauca plašu antivielu atbildi pelēs, taču neaizsargāja pret slimības simptomiem. Rentgenstaru kristalogrāfija un cietvielu KMR uzrādīja trimēra zema pH formas saglabāšanos pēc ķīmiskas VLP funkcionalizācijas. Uz VLP eksponēts stalks inducēja plašu antivielu atbildi, bet nepasargāja no letālām gripas vīrusu infekcijām. Uz vienas daļiņas vienlaicīgi eksponēts stalks un trīskāršs M2 proteīna ektodomēns aizsargāja pret standarta heterologu un heterosubtipisku, kā arī homologu lielas devas gripas vīrusu infekcijām. Atslēgvārdi: gripa, konservatīvi antigēni, hemaglutinīna stalks, M2e proteīns, vīrusiem līdzīgās daļiņas, vakcīnas

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/61054

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
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  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
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- PE1Mathematics
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  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
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  - LS3_2Cell senescence, cell death, autophagy, cell ageing
- LS5Neuroscience and Disorders of the Nervous System
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SHSocial Sciences and Humanities
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