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RESEARCH PRODUCT

Ocular autofluorescence in diabetes mellitus. A review

Teresa Ferrer-blascoRafael J. Pérez-cambrodíSantiago García-lázaroAlejandro CerviñoAna M. Calvo-maroto

subject

0301 basic medicinemedicine.medical_specialtyRetinal pigment epitheliumbusiness.industryEndocrinology Diabetes and Metabolismmedicine.diseaseeye diseases03 medical and health sciencesAutofluorescence030104 developmental biology0302 clinical medicinemedicine.anatomical_structureOphthalmologyDiabetes mellitusCornea030221 ophthalmology & optometryMedicinesense organsMetabolic diseasebusinessMetabolic activity

description

Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of metabolic activity. The aim of the present review is to provide an overview of ocular endogenous fluorophores in the cornea, the crystalline lens, and the retinal pigment epithelium, the effects of diabetes mellitus and therefore the potential of autofluorescence assessment for screening and monitoring changes in diabetic patients.

https://doi.org/10.1111/1753-0407.12423