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RESEARCH PRODUCT

Antibody Pattern of HCV Infection and Hepatocellular Carcinoma in Italy: A Case Control Study

Claudio TiribelliM. A. StaziMaria RapicettaTommaso StroffoliniA. MaglioccoErica VillaT. BertinLory Saveria CrocèP. TrandeMaria ChiaramontePaola ChionneR. G. Simonetti

subject

medicine.medical_specialtyHBsAgbiologybusiness.industryHepatitis C virusCase-control studyDiseasemedicine.disease_causemedicine.diseaseGastroenterologyVirologydigestive system diseasesConfidence intervalInternal medicineHepatocellular carcinomaRelative riskmedicinebiology.proteinAntibodybusiness

description

The association of hepatitis C virus (HCV) infection with hepatocellular carcinoma (HCC) and the presence of a specific antibody pattern was assessed by means of a case-control study conducted in Italy on 65 consecutive newly diagnosed HCC cases and 99 sex- and age-matched control patients with chronic nonhepatic disease. The prevalences of antibody to HCV (anti-HCV) and hepatitis B surface antigen (HBsAg) observed were 66.2% and 24.6%, respectively. The relative risk for the association of each of the two markers with HCC, as calculated by multiple logistic analysis, was 26.9 (95% confidence intervals (CI): 9.9–72.5) for anti-HCV and 11.4 (95% CI: 3.1–41.1) for HBsAg. Thus, they constitute independent risk factors. The attributable population risk (25%) shows that HCV infection plays a major role in the development of HCC in Italy. The study was conducted using 2nd-generation enzyme-linked immunosorbent assay (ELISA) and 2nd- and 3rd-generation recombinant immunoblot assay (RIBA). The analysis of antibody patterns in cases and controls revealed a significantly higher frequency (p <0.02) of the simultaneous occurrence of antibody to both nonstructural and structural viral proteins in HCC cases compared to the control.

yearjournalcountryeditionlanguage
1994-01-01
https://doi.org/10.1007/978-4-431-68255-4_185