6533b820fe1ef96bd12792e3

RESEARCH PRODUCT

Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

Victoria TothGergely BodisAndreas Schwarting

subject

musculoskeletal diseases0301 basic medicinemedicine.medical_specialtyReviewBehcet's diseaseDiseaseHuman leukocyte antigenmedicine.disease_causeOrgan transplantationAutoimmune DiseasesAutoimmunityPathogenesisEpitopes03 medical and health sciencesImmune system0302 clinical medicineRheumatologyHLA AntigensInternal medicineHumansImmunology and AllergyMedicineClinical significanceskin and connective tissue diseases030203 arthritis & rheumatologyHLA-B27business.industryHistocompatibility Antigens Class IInutritional and metabolic diseasesmedicine.diseaseRheumatologyeye diseasesstomatognathic diseases030104 developmental biologyRheumatoid arthritisImmunologybusiness

description

Since the discovery of HLA 60 years ago, it has contributed to the understanding of the immune system as well as of the pathogenesis of several diseases. Aside from its essential role in determining donor-recipient immune compatibility in organ transplantation, HLA genotyping is meanwhile performed routinely as part of the diagnostic work-up of certain autoimmune diseases. Considering the ability of HLA to influence thymic selection as well as peripheral anergy of T cells, its role in the pathogenesis of autoimmunity is understandable. The aim of this paper is to provide a brief overview of the role and current clinical relevance of HLA-B27 in spondyloarthritis and HLA-B51 in Behçet's disease as well as HLA-DQ2/DQ8 in celiac disease and HLA-DRB1 in rheumatoid arthritis and to discuss possible future implications.

yearjournalcountryeditionlanguage
2018-03-07
https://doi.org/10.1007/978-1-4939-8546-3_2