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RESEARCH PRODUCT
Combinatorial synthesis of amino acid- and peptide-carbohydrate conjugates on solid phase
Christopher KallusHorst KunzTill OpatzTobias Wunbergsubject
chemistry.chemical_classificationPeptidomimeticOrganic ChemistryPeptideCarbohydrateBiochemistryCombinatorial chemistryAmino acidTurn (biochemistry)Solid-phase synthesischemistryDrug DiscoverySide chainConjugatedescription
Carbohydrates are useful polyfunctional scaffold molecules which allow the selective attachment of a number of different side chains. The combinatorial solid phase synthesis of diverse amino acid or peptide conjugates of a polyfunctional glucose scaffold based on a set of selectively removable and orthogonally stable protecting groups is described. The resulting carbohydrate-peptide hybrids constitute potential turn mimetics.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-09-01 | Tetrahedron |