ChemInform Abstract: Enantioselective Synthesis of 4-Substituted Dihydrocoumarins Through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes.

6533b820fe1ef96bd12799b1

RESEARCH PRODUCT

ChemInform Abstract: Enantioselective Synthesis of 4-Substituted Dihydrocoumarins Through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes.

Amparo Sanz-marco M. Carmen Muñoz Gonzalo Blay José R. Pedro

subject

chemistry.chemical_compound Enantiopure drug Chemistry Enantioselective synthesis chemistry.chemical_element General Medicine Zinc Diethylzinc Medicinal chemistry Catalysis Conjugate

description

Terminal alkynes (II) react with coumarins (I) in the presence of diethylzinc and chiral bis(hydroxyamide) ligands to give enantiopure dihydrocoumarins (III) substituted with an alkynyl group in C(4) position in good enantioselectivities.

year	journal	country	edition	language
2013-08-22	ChemInform

https://doi.org/10.1002/chin.201337127

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