6533b820fe1ef96bd1279a41
RESEARCH PRODUCT
Enantioselective Henry addition of methyl 4-nitrobutyrate to aldehydes. Chiral building blocks for 2-pyrrolidinones and other derivatives.
Gonzalo BlayJosé R. PedroVictor Hernandez‐olmossubject
LactamsStereoisomerismBiochemistryCatalysisCatalysischemistry.chemical_compoundLactonesPyridineLevulinic acidOrganometallic CompoundsOrganic chemistryMoleculePyrrolidinonesPhysical and Theoretical ChemistryMethyl 4-nitrobutyrateAldehydesMolecular StructureOrganic ChemistryEnantioselective synthesisStereoisomerismNitro CompoundsLevulinic AcidsPyrrolidinonesButyrateschemistryCopperdescription
A catalytic highly enantioselective Henry addition of methyl 4-nitrobutyrate to aldehydes using a Cu(II)-amino pyridine complex as catalyst is described. The products resulting from this reaction constitute a new, highly versatile family of chiral building blocks as a result of the presence of three different functional groups on the molecule. These products have been transformed into nonracemic chiral gamma-lactams, 5-hydroxy-5-substituted levulinic acid derivatives, and delta-lactones.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-12 | Organic letters |