6533b820fe1ef96bd1279a91
RESEARCH PRODUCT
ROLIPRAM INHIBITS PAF-INDUCED AIRWAY MICROVASCULAR LEAKAGE IN GUINEA-PIG - A COMPARISON WITH MILRINONE AND THEOPHYLLINE
Esteban J. MorcilloJulio CortijoJosé M. VallésJ. BouJ. L. Ortizsubject
medicine.medical_specialtyPhosphodiesterase InhibitorsPyridonesGuinea PigsRespiratory SystemVascular permeabilityCapillary Permeabilitychemistry.chemical_compoundTheophyllineInternal medicinemedicineAnimalsPharmacology (medical)TheophyllinePlatelet Activating FactorRolipramPharmacologybiologyCyclic nucleotide phosphodiesterasePlatelet-activating factorbusiness.industryPhosphodiesterasePyrrolidinonesEndocrinologychemistryEnzyme inhibitorbiology.proteinMilrinonebusinessRolipramEvans BlueMilrinonemedicine.drugdescription
The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (non-selective) on PAF (50 ng kg-1; iv)-induced airway vascular leakage have been evaluated in guinea-pigs. Rolipram (3-300 micrograms kg-1; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10-1000 micrograms kg-1; iv) and theophylline (30 mg kg-1; iv) were without effects. The anti-leakage activity of rolipram may be of therapeutic value in asthma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-08-01 |