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RESEARCH PRODUCT
Glial Swelling and Damage by Arachidonic Acid
Andrea Sylvia WinklerOliver KempskiF. StaubJ. PetersAlexander Baethmannsubject
chemistry.chemical_classificationmedicine.medical_specialtyAdverse conditionsRadicalIschemiaFatty acidPhospholipasemedicine.diseasechemistry.chemical_compoundMembraneEndocrinologychemistryInternal medicinemedicineArachidonic acidSwellingmedicine.symptomdescription
Arachidonic acid (AA) is a major constituent of membrane phospholipids in brain tissue. Normally, the free fatty acid is present only in small amounts, but it accumulates under adverse conditions such as ischemia (Kinouchi et al. 1990). The release of free fatty acids involves activation of phospholipases and breakdown of membrane phospholipids. A A in particular is considered to mediate pathological processes. It is a polyunsaturated compound and precursor of prostaglandins, leukotrienes, and oxygen-derived free radicals (Wolfe 1982). In cerebral ischemia concentrations of free AA of up to 0.5mM/kg were found (Kinouchi et al. 1990). But also brain injury and seizures cause increased levels of free AA (Siesjo et al. 1982; Baethmann et al. 1989).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 |