6533b820fe1ef96bd127a662

RESEARCH PRODUCT

Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxicity Studies

Gaetano GiammonaEmanuela Fabiola CraparoAnna MartoranaMaria Luisa BondìGirolamo CirrincioneMelchiorre CervelloPatrizia DianaAntonina Azzolina

subject

Materials scienceCell SurvivalDrug CompoundingPharmaceutical ScienceNanoparticleAntineoplastic AgentsPharmacologynanostructured lipid carrierHuman prostatehuman prostate carcinoma cellPlasmaCell Line TumorElectrochemistryHumansParticle SizeSolubilityCytotoxicityChromatography High Pressure LiquidDrug CarriersGeneral Medicineantitumor drugLipidsControlled releaseBioavailabilitySolubilityPlasma chemistryNanoparticleshuman hepatocellular carcinoma cellcontrolled releaseDrug metabolism

description

This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particular for intravenous administration.

yearjournalcountryeditionlanguage
2007-03-17
10.1080/10717540600739914http://hdl.handle.net/10447/1427