6533b821fe1ef96bd127ac58
RESEARCH PRODUCT
Description of the retention behaviour of solutes in micellar liquid chromatography with organic modifiers: Comparison of two methods
M.c. García-alvarez-coqueRosa María Villanueva-camañasM.j. Medina-hernándezJose Ramon Torres-lapasiosubject
LogarithmChemistryOrganic ChemistryClinical BiochemistryHyperbolic functionAnalytical chemistryThermodynamicsType (model theory)Parameter spaceBiochemistryLinear subspaceAnalytical ChemistryMicellar liquid chromatographyPhase compositionSubspace topologydescription
Two methods for the description of the retention behaviour of solutes in micellar liquid chromatography are compared. One of them divides the parameter space into triangular subspaces, fitting a different equation in each subspace. The second method makes use of a unique equation, valid in the whole parameter space. In both cases, equations of the type log k=f (μ, ϕ), and 1/k=f (μ, ϕ), (μ and ϕ are the concentration of surfactant and alcohol, respectively), were used to describe the retention. The use of the hyperbolic function, 1/k=c0+c1μ+c3μϕ, to describe the whole parameter space yielded the best prediction. When a small portion of the parameter space was modelled, a simpler hyperbolic function, lacking the μϕ term often led to good results. The logarithmic equations usually gave the poorer predictions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-03-01 | Chromatographia |