Die Synthese vono-Acylamino-β-dimethylamino-propiophenonen. 4. Mitt.: Synthese der primären Mannich-Basen

6533b821fe1ef96bd127ac6c

RESEARCH PRODUCT

Die Synthese vono-Acylamino-β-dimethylamino-propiophenonen. 4. Mitt.: Synthese der primären Mannich-Basen

subject

Acylation Propiophenones Primary (chemistry)chemistry Hydrogenolysis Drug Discovery Pharmaceutical Science chemistry.chemical_element Medicinal chemistry Palladium

description

Das durch Umsetzung von 2-Acetamino-β-dimethylamino-propiophenon (IVb) mit Dibenzylamin darstellbare 2-Acetamino-β-dibenzylamino-propiophenon (XXVII) kann hydrogenolytisch mit tels Palladium-Aktivkohle in die entsprechende, nur am aromatischen Stickstoff acetylierte primare Mannich-Base ubergefuhrt werden. In analoger Weise sind auch in 5-Stellung substituierte Derivate des 2-Acetamino-β-amino-propiophenons (XXVIII) zuganglich. Synthesis of 2-Acylamino-β-amino-propiophenones 2-Acetamino-β-dibenzylamino-propiophenone (XXVII) and its derivatives, substituted in 5-position, can be synthetized by reaction of 2-acetamino-β-dimethylamino-propiophenone (IVb) with dibenzylamine. By hydrogenolysis in the presence of palladium charcoal it is possible to convert these compounds into primary Mannich-bases, exclusively acetylated in 2-N-position.

year	journal	country	edition	language
1972-01-01	Archiv der Pharmazie

https://doi.org/10.1002/ardp.19723050608

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