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RESEARCH PRODUCT
Marine Isonitriles and Their Related Compounds.
Ulrich KauhlTill OpatzJens Emsermannsubject
ChinaisothiocyanatesMagnetic Resonance SpectroscopyStereochemistrycarbonimidic dichloridesmalariaPharmaceutical ScienceReviewBiology010402 general chemistry01 natural sciencesantibioticsStructure-Activity RelationshipDrug DiscoveryOrganic chemistryHumansSeawaterPharmacology Toxicology and Pharmaceutics (miscellaneous)lcsh:QH301-705.5isonitriles010405 organic chemistryTerpenesmarine natural productsformamides0104 chemical scienceslcsh:Biology (General)description
Marine isonitriles represent the largest group of natural products carrying the remarkable isocyanide moiety. Together with marine isothiocyanates and formamides, which originate from the same biosynthetic pathways, they offer diverse biological activities and in spite of their exotic nature they may constitute potential lead structures for pharmaceutical development. Among other biological activities, several marine isonitriles show antimalarial, antitubercular, antifouling and antiplasmodial effects. In contrast to terrestrial isonitriles, which are mostly derived from α-amino acids, the vast majority of marine representatives are of terpenoid origin. An overview of all known marine isonitriles and their congeners will be given and their biological and chemical aspects will be discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-14 | Marine drugs |