Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas

6533b821fe1ef96bd127adf0

RESEARCH PRODUCT

Gp80 (clusterin; TRPM-2) mRNA level is enhanced in human renal clear cell carcinomas

Christian Pilarsky Claudia Koch-brandt Uli Rachel Karsten Parczyk

subject

Cancer Research medicine.medical_specialty Biology Kidney TRPM Glycoprotein complex Internal medicine medicine Humans RNA Messenger RNA Neoplasm Carcinoma Renal Cell Glycoproteins Kidney Messenger RNA Clusterin General Medicine Blotting Northern Kidney Neoplasms Neoplasm Proteins Clusterin Endocrinology medicine.anatomical_structure Oncology Apoptosis Clear cell carcinoma Cancer research biology.protein Clear cell Molecular Chaperones

description

The gp80 glycoprotein complex (clusterin, apolipoprotein J, TRPM-2) is a widely expressed protein that has been attributed functions in tissue remodelling, immune defense and transport of lipids and biologically active peptides. The expression of the protein appears to be elevated in several neurodegenerative, apoptotic and malignant processes. We show here that in patients with renal clear cell carcinoma gp80 mRNA is 3-fold overexpressed in tissue of the tumors compared with adjacent non-tumor tissue.

year	journal	country	edition	language
1994-03-01	Journal of Cancer Research and Clinical Oncology

https://doi.org/10.1007/bf01202200

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