6533b821fe1ef96bd127af52

RESEARCH PRODUCT

Phenolic Composition of Hydrophilic Extract of Manna from Sicilian Fraxinus angustifolia Vahl and its Reducing, Antioxidant and Anti-Inflammatory Activity in Vitro

Alessandro AttanzioAntonella D’anneoFrancesco PappalardoMario AllegraLuisa TesoriereFrancesco BoninaMaria A. Livrea

subject

0301 basic medicinemanna bioactivityAntioxidantantioxidantPhysiologyDPPHmedicine.medical_treatmentClinical BiochemistryFraxinus angustifoliaPhytochemicalBiochemistry03 medical and health scienceschemistry.chemical_compound0302 clinical medicineLipid oxidation<i>Fraxinus</i>medicinereducing powerFraxinuFood scienceMolecular BiologyElenolic acidred blood cell oxidationbiologyintestinal bowel disease modellcsh:RM1-950Cell Biologybiology.organism_classificationphytochemicalsTyrosol030104 developmental biologylcsh:Therapeutics. Pharmacologychemistry030220 oncology & carcinogenesisHydroxytyrosolFraxetinmanna

description

Manna, a very singular vegetable product derived from the spontaneous solidification of the sap of some Fraxinus species, has long been known for its mild laxative and emollient properties. In this work, a hydro-alcoholic extract of manna (HME) from Sicilian Fraxinus angustifolia Vahl was investigated using HPLC-DAD to find phenol components and using chemical and biological in vitro assays to determine its reducing, antioxidant and anti-inflammatory capacity. We identified elenolic acid, tyrosol, hydroxytyrosol, catechin, fraxetin, verbascoside, gallic acid, procyanidin-B1, and luteolin 3,7 glucoside, in order of abundance. Measurements of total antioxidant activity by Folin-Ciocalteu reaction and ferric reducing ability (FRAP), as well as of scavenger activity towards ABTS&bull

yearjournalcountryeditionlanguage
2019-10-18Antioxidants
10.3390/antiox8100494http://dx.doi.org/10.3390/antiox8100494