Haemopoietic effects of 7 alpha, 17 beta dimethyltestosterone.

6533b821fe1ef96bd127afe7

RESEARCH PRODUCT

Haemopoietic effects of 7 alpha, 17 beta dimethyltestosterone.

Nicolo' Gebbia Gaetano Leto Francesca Maria Tumminello F. Biondo L. Campio N. D.'alessandre Luciano Rausa

subject

Blood Platelets medicine.medical_specialty Alpha (ethology)Bone Marrow Cells Leukocyte Count Mice Isomerism 7-alpha-17-beyaDimethyltestosterone Bone Marrow Internal medicine Methyltestosterone medicine Animals Transplantation Homologous Platelet Beta (finance)Bone marrow graft Bone Marrow Transplantation Pharmacology business.industry Organ Size Blood Cell Count Hematopoiesis Dimethyltestosterone Endocrinology Immunology Erythrocyte Count Repopulation Female CFU Bone marrow business Spleen

description

Some haematic parameters were investigated in female COBS mice treated with 7 alpha, 17 beta Dimethyltestcsterone (DMT). The drug causes an increase of circulating platelets in normal mice. Bone marrow graft from DMT-treated donors facilitates in irradiated mice repopulation of white blood cells and platelets but lowers % survival. These data are interpreted on the basis of a commitment and a loss of self-maintenance induced by DMT on CFUs compartment. © 1979 The Italian Pharmacological Society.

year	journal	country	edition	language
1979-02-01	Pharmacological research communications

10.1016/s0031-6989(79)80062-4 https://pubmed.ncbi.nlm.nih.gov/155822

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