6533b821fe1ef96bd127b009
RESEARCH PRODUCT
Seizure in isolated brain cryptococcoma: Case report and review of the literature
Ada Maria FlorenaRoberta CostanzoGianvincenzo SparaciaDomenico Gerardo IacopinoGiovanni GrassoAntonio CascioLara Brunassosubject
Pathologymedicine.medical_specialtyCentral nervous systemCase ReportSeizure.03 medical and health sciences0302 clinical medicineCryptococcomaMedicine030212 general & internal medicineCranial nerve dysfunctionbusiness.industryMeningoencephalitisIsolated brainmedicine.diseaseSeizurePathophysiologymedicine.anatomical_structureCentral nervous systemCryptococcosisSurgeryNeurology (clinical)Headachesmedicine.symptombusinessMeningitis030217 neurology & neurosurgerydescription
Background: Central nervous system (CNS) cryptococcosis is an invasive fungal infection predominantly seen among immunosuppressed patients causing meningitis or meningoencephalitis. Rarely, cryptococcosis can affect immunologically competent hosts with the formation of localized CNS granulomatous reaction, known as cryptococcoma. Common symptoms of CNS cryptococcoma are headaches, consciousness or mental changes, focal deficits, and cranial nerve dysfunction. Rarely, seizures are the only presenting symptom. Case Description: We report the case of an immunocompetent patient with a solitary CNS cryptococcoma presenting with a long history of non-responsive generalized seizure who has been successfully operated. Conclusion: CNS cryptococcoma is a rare entity, and in immunocompetent patients, its diagnosis can be challenging. The pathophysiology of lesion-related seizure is discussed along with a review of the pertinent literature.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Surgical Neurology International |