Epigenetic IVD Tests for Personalized Precision Medicine in Cancer

6533b821fe1ef96bd127b05c

RESEARCH PRODUCT

Epigenetic IVD Tests for Personalized Precision Medicine in Cancer

Jesús Beltrán-garcía Jesús Beltrán-garcía Jesús Beltrán-garcía Rebeca Osca-verdegal Rebeca Osca-verdegal Salvador Mena-mollá Salvador Mena-mollá José Luis García-jiménez José Luis García-giménez José Luis García-giménez José Luis García-giménez

subject

0301 basic medicine In Vitro Diagnostic (IVD)lcsh:QH426-470 precision medicine Review Bioinformatics 03 medical and health sciences 0302 clinical medicine microRNA Genetics Medicine Epigenetics cfDNA Genetics (clinical)miRNA Epigenetic biomarkers DNA methylation biology business.industry Cancer epigenetic biomarker Precision medicine medicine.disease lcsh:Genetics 030104 developmental biology Histone 030220 oncology & carcinogenesis DNA methylation circulating nucleosomes biology.protein Molecular Medicine business Glioblastoma

description

Epigenetic alterations play a key role in the initiation and progression of cancer. Therefore, it is possible to use epigenetic marks as biomarkers for predictive and precision medicine in cancer. Precision medicine is poised to impact clinical practice, patients, and healthcare systems. The objective of this review is to provide an overview of the epigenetic testing landscape in cancer by examining commercially available epigenetic-based in vitro diagnostic tests for colon, breast, cervical, glioblastoma, lung cancers, and for cancers of unknown origin. We compile current commercial epigenetic tests based on epigenetic biomarkers (i.e., DNA methylation, miRNAs, and histones) that can actually be implemented into clinical practice.

year	journal	country	edition	language
2019-06-28	Frontiers in Genetics

10.3389/fgene.2019.00621 https://www.frontiersin.org/article/10.3389/fgene.2019.00621/full

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