6533b821fe1ef96bd127b69d
RESEARCH PRODUCT
Function of biomolecules as a probe for studying the effects of organic co-solvents on their conformations
L. Cordonesubject
chemistry.chemical_classificationAqueous solutionAqueous mediumChemistryBiomoleculechemistry.chemical_elementOxygenInorganic ChemistrySolventComputational chemistryMaterials ChemistryOrganic chemistryPhysical and Theoretical ChemistryFunction (biology)MacromoleculeCo solventdescription
Abstract Conformation changes associated with the function of biomolecules can bring out variations of the extent and specific structure of their hydrophobic areas exposed to solvent, with consequent local rearrangements of the solvent. This is one of the channels through which the solvent exerts its role in the functional equilibria of biomolecules. The function of biological macromolecules in perturbed aqueous solvent can therefore be a suitable probe for studying the response of macromolecule-solvent systems to perturbations caused by organic co-solvents. We shall discussed the effects that the presence of some monohydric alcohols and some amides in the aqueous medium have on some thermodynamic parameters related to the reaction of hemoglobin with oxygen. A comparison with other data concerning functional equilibria of bovine liver β-galactosidase and conformational equilibria of ribonuclease and DNA will follow.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1980-01-01 | Inorganica Chimica Acta |