Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome

6533b821fe1ef96bd127b7d1

RESEARCH PRODUCT

Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome

Jordi Salas-salvadó Jordi Salas-salvadó Patricia López-uriarte Mònica Bulló Mònica Bulló Carmen Tormos Lluís Masana Guillermo T. Sáez Patricia Casas-agustench Rosa Nogues Marta Romeu

subject

Male Antioxidant medicine.medical_treatment antioxidant capacity Isoprostanes Critical Care and Intensive Care Medicine medicine.disease_cause Antioxidants Lipid peroxidation chemistry.chemical_compound endothelial function Medicine Nuts chemistry.chemical_classification Metabolic Syndrome Bioquímica y tecnología Nutrition and Dietetics digestive oral and skin physiology food and beverages Arteries Middle Aged 0261-5614 Lipoproteins LDL Biochemistry and technology medicine.anatomical_structure 8-Hydroxy-2'-Deoxyguanosine Fatty Acids Unsaturated Polyunsaturated fatty acid Adult medicine.medical_specialty Endothelium Adolescent DNA damage Estrès oxidatiu Fruita seca -- Aspectes nutritius Bioquímica i biotecnologia Young Adult Lipid oxidation Internal medicine Humans Aged business.industry Deoxyguanosine Endoteli vascular medicine.disease Diet Oxidative Stress Endocrinology chemistry DNA damage Vascular Resistance Endothelium Vascular Metabolic syndrome business Oxidative stress Biomarkers

description

Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome BACKGROUND & AIMS: Oxidative stress has a key role in atherosclerosis, cancer and other chronic diseases. Some bioactive compounds in nuts have been implicated in antioxidant activities. OBJECTIVE: We assessed how nut consumption affected several markers of oxidation and endothelial function (EF) in metabolic syndrome (MetS) patients. PATIENTS AND METHODS: A randomized, controlled, parallel feeding trial was conducted on 50 MetS adults who were recommended a healthy diet supplemented or not with 30 g of mixed nuts (Nut and Control groups, respectively) every day for 12 weeks. The plasma antioxidant capacity (AC), oxidized LDL (oxLDL), conjugated diene (CD) formation, urine 8-isoprostanes, DNA damage assessed by yield of urine 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), and EF assessed by peripheral artery tonometry (PAT) and biochemical markers, were measured at baseline and the end of the intervention. RESULTS: No significant differences in changes between groups were observed in AC, oxLDL, CD, 8-isoprostanes or EF during the intervention, whereas the reduction in DNA damage was significant in the Nut group compared to Control group (P < 0.001). CONCLUSION: Nut consumption has no deleterious effect on lipid oxidation. The decrease in DNA damage observed in this study could contribute to explain the beneficial effects of regular nut consumption on some MetS features and several chronic diseases.

year	journal	country	edition	language
2010-06-01

http://hdl.handle.net/20.500.11797/PC1725