Immunological and immunogenetic markers in sporadic Alzheimer’s disease

6533b821fe1ef96bd127b7f9

RESEARCH PRODUCT

Immunological and immunogenetic markers in sporadic Alzheimer’s disease

Giuseppina Colonna Romano Domenico Lio Giuseppina Candore Calogero Caruso Letizia Scola

subject

Aging Disease Immunogenetics Diagnostic tools Proteomics Pathogenesis Apolipoproteins E Alzheimer Disease Humans Medicine Oligonucleotide Array Sequence Analysis Inflammation Alzheimer’s disease cytokines immunogenetics inflammation proteomics Polymorphism Genetic Geriatrics gerontology business.industry DNA Risk evaluation Gene Expression Regulation Positron-Emission Tomography Immunology Cytokines Microglia Geriatrics and Gerontology business Biomarkers Acute-Phase Proteins

description

Background: Common polymorphisms of genes controlling inflammation-modulating cytokines and acute-phase proteins which play important roles in the pathogenesis of Alzheimer''s disease (AD) have been shown to be associated with AD. Aims: The immunological and immunogenetic markers potentially useful for the AD risk evaluation and diagnosis are briefly reviewed. Conclusion: The state-of-the-art of immunological and immunogenetic markers of AD indicates that new tools and strategies are necessary to identify gene products useful as diagnostic tools.

year	journal	country	edition	language
2006-05-17	Aging Clinical and Experimental Research

https://doi.org/10.1007/bf03327434

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