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RESEARCH PRODUCT
Frequency and determinants for hemorrhagic transformation of posterior cerebral stroke : Posterior ischemic stroke and hemorrhagic transformation.
Sergio MastrilliValeria TerrusoCaterina SarnoPaolo RagoneseGiovanni SavettieriMarco D'amelioLuana GentileFrancesca ValentinoPaolo Aridonsubject
medicine.medical_specialtymedicine.medical_treatmentCerebral strokeLogistic regressionGeneral Biochemistry Genetics and Molecular BiologyBrain ischemia03 medical and health sciences0302 clinical medicineInternal medicineEpidemiologymedicinebiochemistry030212 general & internal medicineStrokebusiness.industryposterior ischemic strokegenetics and molecular biology (all)epidemiology; hemorrhagic transformation; posterior ischemic stroke; biochemistry genetics and molecular biology (all)General MedicineThrombolysismedicine.diseaseSurgeryhemorrhagic transformationIschemic strokeCardiologyepidemiologyComplicationbusiness030217 neurology & neurosurgerydescription
BACKGROUND: hemorrhagic transformation is a threatening ischemic stroke complication. Frequency of hemorrhagic transformation differs greatly among studies, and its risk factors have been usually studied in patients with anterior ischemic stroke who received thrombolytic therapy. We evaluated, in a hospital-based series of patients with posterior ischemic stroke not treated with thrombolysis, frequency and risk factors of hemorrhagic transformation. Patients with posterior circulation stroke were seen in our Department during the period January 2004 to December 2009. Demographic and clinical information were collected. We estimated risk for spontaneous hemorrhagic transformation by means of uni- and multivariate logistic regression analyses. RESULTS: 119 consecutive patients were included (73 males, 61.3%). Hemorrhagic transformation was observed in 7 patients (5.9%). Only clinical worsening was significantly associated with hemorrhagic transformation (OR 6.8, 95% CI 1.3-34.5). CONCLUSIONS: Our findings indicate that patients with posterior have a low risk of spontaneous hemorrhagic transformation, suggesting that these patients might have greater advantage from intravenous thrombolysis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-13 |