6533b821fe1ef96bd127b9a5

RESEARCH PRODUCT

Age- and sex-dependent differences in patients with severe asthma included in the German Asthma Net cohort.

Roland BuhlFelix J.f. HerthKatrin MilgerEckard HamelmannMonika GappaNora DrickHendrik SuhlingStephanie KornJan Fuge

subject

MalePediatricsDiseaseOmalizumabSeverity of Illness IndexGermanCohort Studies0302 clinical medicineGermany030212 general & internal medicineAnti-Asthmatic AgentsChildAged 80 and overAge FactorsAntibodies MonoclonalMiddle AgedBronchodilator AgentsChild PreschoolCohortlanguageFemalePulmonary and Respiratory MedicineAdultmedicine.medical_specialtyAdolescentSevere asthmamacromolecular substancesAge and sex03 medical and health sciencesYoung AdultSex FactorsAge groupsmedicineHumansIn patientGlucocorticoidsAsthmaAgedMaximal Expiratory Flow RateRetrospective Studiesbusiness.industryInfantImmunoglobulin Emedicine.diseaselanguage.human_languageAsthmarespiratory tract diseases030228 respiratory systemQuality of Lifebusiness

description

Severe asthma affects less than 5% of asthmatics, but is associated with high costs and increased mortality. The aim of this study was to assess age- and sex-dependent differences in this patient group.Retrospective analysis of 1317 children and adults with severe asthma who are included in the German Asthma Net registry.There were more adults than children in the registry and patients' mean age was 52. Apart from children18 years, there were more women (57%) than men. The age of first diagnosis ranged from 0 to 76 years. 38% of patients had a positive bronchial reversibility after short acting bronchodilators. Quality of life, FEV1 and MEF 25 decreased with older age whereas treatment with oral steroids and monoclonal antibodies increased. An anti-eosinophil treatment was most frequently used in patients aged around 57 years, while an anti-IgE treatment was used in all age-groups including children. There were sex-dependent differences with lower values in men for FEV1, FVC, MEF 25 and DLCO. Yet, women were more frequently unable to work than men due to the disease.In patients with severe asthma, clinical characteristics, but also treatments differed between age groups and between the sexes, reflecting different phenotypes of the disease.

yearjournalcountryeditionlanguage
2020-02-01Respiratory medicine
10.1016/j.rmed.2019.105858https://pubmed.ncbi.nlm.nih.gov/31916535