6533b821fe1ef96bd127b9ef
RESEARCH PRODUCT
Biological aggressiveness evaluation in prostate carcinomas: immunohistochemical analysis of PCNA and p53 in a series of Gleason 6 (3+3) adenocarcinomas
Anna MartoranaDarvinio MelloniA. PalmaFelicia FarinaDaniela CabibiElisabetta BarresiF AragonaFrancesca RappaFrancesco Cappellosubject
MalePathologymedicine.medical_specialtyHistologyProliferative indexBiophysicsStatistical differenceSettore MED/08 - Anatomia PatologicaAdenocarcinomaBiologyP53 MutationProstateProliferative index; Prostate cancerogenesis; Tumoral differentiation; Tumoral prognosis; Cell Biology; Anatomy; Animal Science and Zoology; Developmental BiologyProliferating Cell Nuclear AntigenBiomarkers TumormedicineHumansProstate tumorsIntermediate Gradelcsh:QH301-705.5Tumoral differentiationBiologic markerProstatic NeoplasmsCell BiologyImmunohistochemistryProliferating cell nuclear antigenmedicine.anatomical_structurelcsh:Biology (General)Prostate cancerogenesibiology.proteinImmunohistochemistryTumoral prognosiAnimal Science and ZoologyAnatomyTumor Suppressor Protein p53Developmental Biologydescription
We selected 63 prostate tumors with Gleason's grade 6 (3+3), commonly showing both tubular and cribrous patterns. We compared in both patterns the expression of two of the most used biologic markers: PCNA and p53, with the aim to verify the validity of the Gleason's grading system to compare the morphologic grade with biologic aggressiveness and prognostic value. We did not find any statistical difference in the protein immunopositivity, indicating that both patterns could have identical biologic behaviour; then we confirmed the validity of Gleason's system for considering both tubular and cribrous patterns as an intermediate grade of tumoral differentiation. Moreover, we found a linear relationship between the increase of PCNA and the accumulation of mutated p53; this datum could confirm the hypothesis that p53 mutation is a late event in prostate carcinogenesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-01-01 | European Journal of Histochemistry |