6533b821fe1ef96bd127ba2b
RESEARCH PRODUCT
Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.
Niels H. GehringJean-yves RoignantJean-yves Roignantsubject
Regulation of gene expression0303 health sciencesRNA SplicingIntronRNAEukaryotaRNA-binding proteinComputational biologyBiologyIntronsChromatin03 medical and health sciencesAlternative Splicing0302 clinical medicineCircular RNARNA splicingGene expressionGeneticsRNA PrecursorsHumansRNA Messenger030217 neurology & neurosurgery030304 developmental biologydescription
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene expression. The identification of the actual splice sites and the proper removal of introns are essential for the production of the desired mRNA isoforms and their encoded proteins. While the basic mechanisms of splicing regulation are well understood, recent work has uncovered a growing number of noncanonical splicing mechanisms that play key roles in the regulation of gene expression. In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications. We further discuss the recent development of emerging splicing mechanisms, such as recursive and back splicing, and their impact on gene expression.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 | Trends in genetics : TIG |