6533b821fe1ef96bd127be39
RESEARCH PRODUCT
Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration
Roberto ScaffaroFrancesco LoprestiLuigi BottaSalvatrice RigogliusoGiulio Ghersisubject
particulate leachingMaterials Chemistry2506 Metals and AlloyPCL multilayer scaffoldPolymers and PlasticSettore ING-IND/22 - Scienza E Tecnologia Dei Materialimelt mixingpore size gradientSettore BIO/10 - BiochimicaOrganic Chemistryinterface tissue engineeringSettore ING-IND/34 - Bioingegneria Industrialefunctionally graded scaffoldChemical Engineering (all)description
In order to develop scaffold able to mimic the natural gradient properties of tissues, biphasic and triphasic approaches were adopted. In this work, polycaprolactone/polyethylene glycol (PCL/PEG) scaffolds were prepared by using a combination of melt mixing and selective leaching without harmful solvents. The method permitted to develop three-layer scaffolds with high control of porosity and pore size. The mechanical properties were evaluated under physiological condition in order to simulate the real conditions of work. Co-culture of osteoblastic and fibroblastic mice cells were carried out in order to study the differential cellular permeation through the different pore size layers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |