6533b821fe1ef96bd127c06f

RESEARCH PRODUCT

Risk stratification in non-ST elevation acute coronary syndromes

Vicente BertomeuMauricio PellicerLorenzo FácilaJuan SanchisJulio NúñezÀNgel LlàcerFrancisco J. ChorroVicent Bodí

subject

Acute coronary syndromemedicine.medical_specialtyHomocysteinebiologyUnstable anginabusiness.industryST elevationC-reactive proteinmedicine.diseaseTroponinchemistry.chemical_compoundchemistryInternal medicineTroponin Imedicinebiology.proteinCardiologyMyocardial infarctionCardiology and Cardiovascular Medicinebusiness

description

Abstract Introduction: In acute coronary syndromes, myocardial damage markers and acute-phase reactants predict adverse cardiac events. The aim of this study was to define the fitted prognostic value of the most widely used variables of necrosis and inflammation as well as of homocysteine. Methods and results: Troponin I, high-sensitivity C-reactive protein, fibrinogen and homocysteine were measured in 515 consecutive patients admitted to our institution for non-ST elevation acute coronary syndrome. The risk for major events (death or nonfatal myocardial infarction) through 6 months of follow-up was analysed. In the univariate analysis, all markers were related to major events ( p 11 mg/l (2.1 [1.2–3.8] p =0.007) and troponin I >3 ng/ml (1.9 [1.1–3.4] p =0.03). Moreover, the rate of major events was significantly higher ( p Conclusion: In non-ST elevation acute coronary syndromes elevated levels of troponin I, C-reactive protein, fibrinogen and homocysteine are strongly related to the risk of major events. The prognostic value of troponin I and C-reactive protein is independent and additive with respect to each other.

yearjournalcountryeditionlanguage
2005-02-01International Journal of Cardiology
https://doi.org/10.1016/j.ijcard.2003.10.046