6533b821fe1ef96bd127c098

RESEARCH PRODUCT

Multizentrische Phase II — Studie der Arbeitsgruppe Lebermetastasen zur wöchentlichen intraarteriellen 24 h Hochdosistherapie mit 5-FU und Folinsäure (FA) bei Lebermetastasen kolorektaler Tumoren

E. Staib-seblerM. LorenzH D SaegerP. MattesT JungingerHans-helge Müller

subject

medicine.medical_specialtybusiness.industryNauseaGastroenterologySurgeryFolinic acidDiarrheaHepatic arterial infusionMulticenter trialInternal medicineToxicityMedicinemedicine.symptombusinessmedicine.drug

description

This prospective multicenter trial was performed to determine the response rate, toxicity and applicability of continuous 24 h hepatic arterial infusion of high-dose 5-FU and folinic acid. An improved response rate (60.5% in non-pretreated patients) was however associated with many systemic side-effects (340/509), mainly nausea and diarrhea. Therefore this treatment should be applied only in selected patients in specialized centers.

yearjournalcountryeditionlanguage
1998-01-01
https://doi.org/10.1007/978-3-642-45774-6_351