6533b821fe1ef96bd127c152

RESEARCH PRODUCT

Flow-injection spectrofluorimetric determination of paracetamol

J. Martínez CalatayudC. Gómez Benito

subject

AnalyteChromatographyChemistryPotassiumdigestive oral and skin physiologyRelative standard deviationFluorescence spectrometrychemistry.chemical_elementInjection rateBiochemistryAnalytical ChemistryEnvironmental ChemistryQuantitative analysis (chemistry)Spectroscopy

description

Abstract A flow-injection spectrofluorimetric determination of paracetamol is reported, based on the oxidation of the analyte with potassium hexacyanoferrate(III) immobilized on an anion-exchange resin, the fluorescence being enhanced with N,N′-dimethylformamide. Concentrations of paracetamol in the range 0.04–17.60 mg l−1 are determined with a relative standard deviation of 1.5%. The injection rate is 25 samples h−1. The influence of foreign species and the determination of paracetamol in several pharamaceutical formulations are also reported.

https://doi.org/10.1016/s0003-2670(00)86424-7