6533b821fe1ef96bd127c27d

RESEARCH PRODUCT

Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin

Xavier Fernàndez-busquetsCarla CaddeoAnna Maria FaddaJosé Esteban PerisMaria ManconiMaria Letizia MancaGemma GutiérrezMaría MatosIris UsachOctavio Díez-salesOctavio Díez-sales

subject

Materials scienceCell SurvivalSwineSkin AbsorptionBiomedical EngineeringPhospholipidPharmaceutical ScienceMedicine (miscellaneous)Bioengineering02 engineering and technologyPoloxamerResveratrol010402 general chemistry01 natural sciencesCell Linechemistry.chemical_compoundMiceIn vivoGallic AcidStilbenesGlycerolAnimalsEdemaGeneral Materials SciencePhenolsSkinLiposomePhenolVesicleAnti-Inflammatory Agents Non-SteroidalSkin inflammationPoloxamerFibroblasts021001 nanoscience & nanotechnology0104 chemical sciencesOxidative StresschemistryBiochemistryResveratrolLiposomesPhospholipid vesicleBiophysicsMolecular MedicineFemale0210 nano-technology

description

[EN] Resveratrol and gallic acid, a lipophilic and a hydrophilic phenol, were co-loaded in innovative, biocompatible nanovesicles conceived for ensuring the protection of the skin from oxidative-and inflammatory-related affections. The basic vesicles, liposomes and glycerosomes, were produced by a simple, one-step method involving the dispersion of phospholipid and phenols in water or water/glycerol blend, respectively. Liposomes and glycerosomes were modified by the addition of poloxamer, a stabilizer and viscosity enhancer, thus obtaining viscous or semisolid dispersions of structured vesicles. The vesicles were spherical, unilamellar and small in size (similar to 70 nm in diameter). The superior ability of the poloxamer-structured vesicles to promote the accumulation of both phenols in the skin was demonstrated, as well as their low toxicity and great ability to protect fibroblasts from chemically-induced oxidative damage. The in vivo administration of the vesicular phenols on TPA (phorbol ester)-exposed skin led to a significant reduction of oedema and leukocyte infiltration. (C) 2017 Elsevier Inc. All rights reserved.

yearjournalcountryeditionlanguage
2017-01-01
10.1016/j.nano.2016.12.017http://hdl.handle.net/10251/112508