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RESEARCH PRODUCT

Evaluation of serum levels of soluble CD4, CD8 and β2-microglobulin in visceral human leishmaniasis

Francesco ArcoleoRenato MaltaCarla GiordanoEnrico CillariGiorgio StassiG. GambinoC. MocciaroGiustina VitaleA. SpinelliSalvatore Milano

subject

AdultLeukopeniaBeta-2 microglobulinCD8 AntigensImmunologyLeishmaniasisBiologymedicine.diseaseImmunophenotypingPathogenesisVisceral leishmaniasisT-Lymphocyte SubsetsCD4 AntigensImmunologymedicineHumansLeishmaniasis VisceralImmunology and AllergySecretionmedicine.symptombeta 2-MicroglobulinBeta (finance)CD8Research Article

description

SUMMARY The levels of soluble CD4 (sCD4), sCD8 and β2-microglobulin (β2-M) were measured in sera from patients with visceral leishmaniasis during the course of infection. Levels of sCD4. sCD8 and β2-M were raised significantly above levels In normal sera and returned to the normal range after recovery. The decrease in the levels of CDS was related to a reduction of anaemia, leukopenia and thrombocytopenia. In contrast, sCD4 levels fluctuated during the period of infection. β2-M returned within normal range more rapidly than sCD8 secretion. Our results suggest that T cells are activated during infection, and that it is also possible that the raised levels of these soluble molecules play a role in the impairment of protective immunity.

yearjournalcountryeditionlanguage
1994-08-01Clinical and Experimental Immunology
https://doi.org/10.1111/j.1365-2249.1994.tb06081.x