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RESEARCH PRODUCT
Cross-sectional associations of objectively-measured sleep characteristics with obesity and type 2 diabetes in the PREDIMED-Plus trial.
Aurora Bueno-cavanillasAurora Bueno-cavanillasJulia WärnbergJulia WärnbergAndrés Díaz-lópezMònica BullóMiguel Ruiz-canelaMiguel Ruiz-canelaF. Javier Barón-lópezF. Javier Barón-lópezMacarena Torrego EllacuríaNapoleón Pérez-farinósNapoleón Pérez-farinósAbdurrahman Adlbi SibaiAbdurrahman Adlbi SibaiXavier PintóPilar Buil-cosialesPilar Buil-cosialesJosep A. TurJosep A. TurItziar AbeteItziar AbeteEmilio RosEmilio RosNuria Rosique-estebanAlbert SanllorenteJordi Salas-salvadóFernando ArósFrancisco J. TinahonesJesús VioqueMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezRebeca Fernández-carriónRebeca Fernández-carriónAntoni ColomJose M. OrdovasJose M. OrdovasRamon EstruchRamon EstruchChristopher PapandreouManoli García De La HeraDolores CorellaDolores CorellaDora RomagueraJ. Alfredo MartínezJ. Alfredo MartínezAntonio Garcia-riosAntonio Garcia-riosLluis Serra-majemLluis Serra-majemOlga CastañerJosep Vidalsubject
Malemedicine.medical_specialtyWaist030209 endocrinology & metabolismType 2 diabetesOverweightBody Mass Index03 medical and health sciences0302 clinical medicineRisk FactorsPhysiology (medical)Internal medicineSleep Initiation and Maintenance DisordersAccelerometrymedicineHumansObesityAdiposityAgedMetabolic Syndromebody compositionnight-to-night sleep variabilitybusiness.industryMiddle Agedmedicine.diseaseObesityConfidence intervalCross-Sectional StudiesDiabetes Mellitus Type 2sleep durationFemaleNeurology (clinical)Android fat distributiontype 2 diabetesmedicine.symptomMetabolic syndromeWaist CircumferencebusinessSleepBody mass index030217 neurology & neurosurgerydescription
Study Objectives: To examine independent and combined associations of sleep duration and sleep variability with body composition, obesity and type 2 diabetes (T2D) in elders at high cardiovascular risk. Methods: Cross-sectional analysis of 1986 community-dwelling elders with overweight/obesity and metabolic syndrome from PREDIMEDPlus trial. Associations of accelerometry-derived sleep duration and sleep variability with body mass index (BMI), waist circumference (WC) and body composition were assessed fitting multivariable-adjusted linear regression models. Prevalence ratios (PR) and 95% confidence intervals (CI) for obesity and T2D were obtained using multivariable-adjusted Cox regression with constant time. "Bad sleepers" (age-specific non-recommended sleep duration plus sleep variability above the median) and "good sleepers" (age-specific recommended sleep duration plus sleep variability below the median) were characterized by combining sleep duration and sleep variability, and their associations with these outcomes were examined. Results: One hour/night increment in sleep duration was inversely associated with BMI (beta-0.38 kg/m(2) [95% CI -0.54, -0.23]), WC (beta-0.86 cm [95% CI -1.25, -0.47]), obesity (PR 0.96 [95% CI 0.93, 0.98]), T2D (PR 0.93 [95% CI 0.88, 0.98]) and other DXA-derived adiposity-related measurements (android fat and trunk fat, all p <.05). Each 1-hour increment in sleep variability was positively associated with T2D (PR 1.14 [95% CI 1.01, 1.28]). Compared with "good sleepers," "bad sleepers" were positively associated with obesity (PR 1.12 [95% CI 1.01, 1.24]) and T2D (PR 1.62 [95% CI 1.28, 2.06]). Conclusions: This study revealed cross-sectional associations of sleep duration with adiposity parameters and obesity. Sleep duration and sleep variability were associated with T2D. Considering simultaneously sleep duration and sleep variability could have additional value, particularly for T2D, as they may act synergistically.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |