6533b821fe1ef96bd127c345
RESEARCH PRODUCT
Arterial stiffness indexes and serum cytokine levels in seronegative spondyloarthritis: relationships between stiffness markers and metabolic and immunoinflammatory variables
Antonino TuttolomondoRosaria PecoraroCarmelo Butta'Domenico Di RaimondoAngelo FerranteFrancesco CicciaChiara BelliaAnnarita GiardinaMaria CiaccioAntonio PintoMarcello CiaccioV. Della CorteA. Raffasubject
Malemedicine.medical_specialtyImmunologyInterleukin-1betaPulse Wave AnalysiGastroenterologySeverity of Illness IndexRheumatologyInternal medicinemedicineImmunology and AllergyOutpatient clinicInterleukin 6Pulse wave velocityCytokineMultivariate Analysibiologybusiness.industryInterleukin-6Tumor Necrosis Factor-alphaBiomarkers; C-Reactive Protein; Case-Control Studies; Cytokines; Female; Humans; Interleukin-1beta; Interleukin-6; Male; Middle Aged; Multivariate Analysis; Pulse Wave Analysis; Spondylarthritis; Tumor Necrosis Factor-alpha; Vascular Stiffness; Severity of Illness IndexC-reactive proteinSpondylarthritiInterleukinGeneral MedicineBiomarkerMiddle Agedmedicine.diseaseRheumatologyBlood pressureC-Reactive ProteinImmunologybiology.proteinArterial stiffnessFemalebusinessCase-Control StudieHumanVascular Stiffnedescription
Objective: The aim of this study was to investigate the relationship between immunoinflammatory markers and indexes of arterial stiffness in patients with seronegative spondyloarthritis (SpA).Method: We enrolled consecutive patients with inflammatory seronegative SpA referred to a rheumatology outpatient clinic. Control subjects were patients admitted in the same period for any cause other than chronic inflammatory disease or acute cardiovascular and cerebrovascular events. Carotid-femoral pulse wave velocity (PWV) was measured and the aortic pressure waveform was used to calculate the augmentation index (Aix). We also evaluated plasma levels of C-reactive protein (CRP), interleukin (IL)-1β, tumour necrosis factor (TNF)-α, and interleukin (IL)-6 as markers of immunoinflammatory activation.Results: This study enrolled 53 patients with SpA and 55 control subjects. After adjustment for blood glucose, cholesterol, and triglyceride levels, and systolic (SBP) and diastolic blood pressure (DBP), patients with se...
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-07-14 |