ChemInform Abstract: Unique Regioselectivity in the C(sp3)-H α-Alkylation of Amines: The Benzoxazole Moiety as a Removable Directing Group.

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RESEARCH PRODUCT

ChemInform Abstract: Unique Regioselectivity in the C(sp3)-H α-Alkylation of Amines: The Benzoxazole Moiety as a Removable Directing Group.

subject

chemistry.chemical_compound chemistry Hydride Substituent Nucleophilic substitution Regioselectivity Hydroxide Moiety General Medicine Alkylation Benzoxazole Medicinal chemistry

description

The benzoxazol-2-yl substituent is easily introduced by oxidative coupling or nucleophilic substitution and can be removed by hydroxide or by hydride reduction.

year	journal	country	edition	language
2015-01-29	ChemInform

https://doi.org/10.1002/chin.201507221

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