6533b822fe1ef96bd127cada

RESEARCH PRODUCT

Organoelement derivatives of steroids: Synthesis and structural features of organosilicon, -tin and -lead derivatives of cholesterol and desoxycholic acid

subject

description

Some organo-Main-Group-IV-element compounds of steroids of the type R3M(COL), R2Sn(COL)2 and (R3M)2(HDCA) (where R = Me or Ph; M = Si, Sn and Pb; HCOL = cholest-5-en-3β-ol; H3DCA = 3α, 12α-dihydroxy-5β-cholan-24-oic acid), have been synthesized. The structures of these compounds have been investigated by vibrational, mass, NMR (1H, 13C, 29Si, 119Sn and 207Pb) and 119Sn Mossbauer spectroscopy. For Me3Sn(COL) both in solution and in the solid state an associated structure with distorted trigonal bipyramidal geometry around tin and three-coordinated oxygen atoms is postulated. Discrete tetrahedral geometries are assigned to Ph3M(COL) complexes and to R2Sn(COL)2 complexes in solution. The latter compounds probably have an associated distorted trigonal bipyramidal structure in the solid state. The complexes (Ph3M)2(HDCA) also have tetrahedral geometries around the central atoms M in solution, but for (Ph3Sn)2(HDCA) a polymeric structure with both tin atoms pentacoordinated in the solid state is proposed.