0000000000371078

AUTHOR

Anil Kumar Saxena

showing 3 related works from this author

ChemInform Abstract: Organoelement Derivatives of Steroids: Synthesis and Structural Characterization of Diorganotin Chloride Adducts of Hormones.

1987

Abstract Ten new diorganotin dichloride adducts of hormones of the type R 2 SnCl 2 ·2L [where R = Me, Et, n-Bu, Oct and Ph; L = 4-androsten-17s-ol-3-one ( A ); 5-androsten-3s-ol-17-one ( B ); 4-androsten-17α- methyl-17s-ol-3-one ( C ) and 3,17-dihydroxy-5- pregnene-20-one ( D )] have been prepared and characterized at 297 K and 223 K. Spectroscopic measurements (IR; Raman; 1 H, 13 C, 119 Sn NMR) suggest the dissociation or fast ligand exchange in solution at 297 K. Hexa-coordinated adducts with bonding through carbonyl oxygen and trans -R groups in octahedral geometry are formulated at 223 K.

Ligandchemistry.chemical_elementGeneral MedicineOxygenChlorideMedicinal chemistryDissociation (chemistry)Adductsymbols.namesakechemistryOctahedral molecular geometrysymbolsmedicineRaman spectroscopyHormonemedicine.drugChemInform
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Organoelement derivatives of steroids: Synthesis and structural features of organosilicon, -tin and -lead derivatives of cholesterol and desoxycholic…

1987

Some organo-Main-Group-IV-element compounds of steroids of the type R3M(COL), R2Sn(COL)2 and (R3M)2(HDCA) (where R = Me or Ph; M = Si, Sn and Pb; HCOL = cholest-5-en-3β-ol; H3DCA = 3α, 12α-dihydroxy-5β-cholan-24-oic acid), have been synthesized. The structures of these compounds have been investigated by vibrational, mass, NMR (1H, 13C, 29Si, 119Sn and 207Pb) and 119Sn Mossbauer spectroscopy. For Me3Sn(COL) both in solution and in the solid state an associated structure with distorted trigonal bipyramidal geometry around tin and three-coordinated oxygen atoms is postulated. Discrete tetrahedral geometries are assigned to Ph3M(COL) complexes and to R2Sn(COL)2 complexes in solution. The latte…

StereochemistrySolid-statechemistry.chemical_elementGeneral ChemistryInorganic ChemistryCrystallographychemistry.chemical_compoundTrigonal bipyramidal molecular geometryOxygen atomchemistryMössbauer spectroscopyTinOrganosiliconDesoxycholic acidApplied Organometallic Chemistry
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Organoelement derivatives of steroids: synthesis and structural characterization of diorganotin chloride adducts of hormones

1986

Abstract Ten new diorganotin dichloride adducts of hormones of the type R 2 SnCl 2 ·2L [where R = Me, Et, n-Bu, Oct and Ph; L = 4-androsten-17s-ol-3-one ( A ); 5-androsten-3s-ol-17-one ( B ); 4-androsten-17α- methyl-17s-ol-3-one ( C ) and 3,17-dihydroxy-5- pregnene-20-one ( D )] have been prepared and characterized at 297 K and 223 K. Spectroscopic measurements (IR; Raman; 1 H, 13 C, 119 Sn NMR) suggest the dissociation or fast ligand exchange in solution at 297 K. Hexa-coordinated adducts with bonding through carbonyl oxygen and trans -R groups in octahedral geometry are formulated at 223 K.

ChemistryStereochemistrymedicine.medical_treatmentchemistry.chemical_elementNuclear magnetic resonance spectroscopyChlorideOxygenDissociation (chemistry)AdductSteroidInorganic Chemistrysymbols.namesakeOctahedral molecular geometryMaterials ChemistrymedicinesymbolsPhysical and Theoretical ChemistryRaman spectroscopymedicine.drugInorganica Chimica Acta
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