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RESEARCH PRODUCT
Organoelement derivatives of steroids: synthesis and structural characterization of diorganotin chloride adducts of hormones
Friedo HuberG. C. StoccoAnil Kumar SaxenaA. GirasoloLorenzo Pelleritosubject
ChemistryStereochemistrymedicine.medical_treatmentchemistry.chemical_elementNuclear magnetic resonance spectroscopyChlorideOxygenDissociation (chemistry)AdductSteroidInorganic Chemistrysymbols.namesakeOctahedral molecular geometryMaterials ChemistrymedicinesymbolsPhysical and Theoretical ChemistryRaman spectroscopymedicine.drugdescription
Abstract Ten new diorganotin dichloride adducts of hormones of the type R 2 SnCl 2 ·2L [where R = Me, Et, n-Bu, Oct and Ph; L = 4-androsten-17s-ol-3-one ( A ); 5-androsten-3s-ol-17-one ( B ); 4-androsten-17α- methyl-17s-ol-3-one ( C ) and 3,17-dihydroxy-5- pregnene-20-one ( D )] have been prepared and characterized at 297 K and 223 K. Spectroscopic measurements (IR; Raman; 1 H, 13 C, 119 Sn NMR) suggest the dissociation or fast ligand exchange in solution at 297 K. Hexa-coordinated adducts with bonding through carbonyl oxygen and trans -R groups in octahedral geometry are formulated at 223 K.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-12-01 | Inorganica Chimica Acta |