6533b7dbfe1ef96bd126fe3c

RESEARCH PRODUCT

ChemInform Abstract: Organoelement Derivatives of Steroids: Synthesis and Structural Characterization of Diorganotin Chloride Adducts of Hormones.

Lorenzo PelleritoA. GirasoloFriedo HuberAnil Kumar SaxenaG. C. Stocco

subject

Ligandchemistry.chemical_elementGeneral MedicineOxygenChlorideMedicinal chemistryDissociation (chemistry)Adductsymbols.namesakechemistryOctahedral molecular geometrysymbolsmedicineRaman spectroscopyHormonemedicine.drug

description

Abstract Ten new diorganotin dichloride adducts of hormones of the type R 2 SnCl 2 ·2L [where R = Me, Et, n-Bu, Oct and Ph; L = 4-androsten-17s-ol-3-one ( A ); 5-androsten-3s-ol-17-one ( B ); 4-androsten-17α- methyl-17s-ol-3-one ( C ) and 3,17-dihydroxy-5- pregnene-20-one ( D )] have been prepared and characterized at 297 K and 223 K. Spectroscopic measurements (IR; Raman; 1 H, 13 C, 119 Sn NMR) suggest the dissociation or fast ligand exchange in solution at 297 K. Hexa-coordinated adducts with bonding through carbonyl oxygen and trans -R groups in octahedral geometry are formulated at 223 K.

yearjournalcountryeditionlanguage
1987-04-14ChemInform
https://doi.org/10.1002/chin.198715297