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RESEARCH PRODUCT

Comment on “Local impermeant anions establish the neuronal chloride concentration”

Werner KilbSergei KirischukHeiko J. Luhmann

subject

chemistry.chemical_classificationMultidisciplinaryPolarity (international relations)ChemistryGABAA receptorReceptor signalingChlorideExtracellular matrixBiochemistryCytoplasmmedicineGlycoproteinIntracellularmedicine.drug

description

Glykys et al . (Reports, 7 February 2014, p. 670) proposed that cytoplasmic impermeant anions and polyanionic extracellular matrix glycoproteins establish the local neuronal intracellular chloride concentration, [Cl – ] i , and thereby the polarity of γ-aminobutyric acid type A (GABA A ) receptor signaling. The experimental procedures and results in this study are insufficient to support these conclusions. Contradictory results previously published by these authors and other laboratories are not referred to.

yearjournalcountryeditionlanguage
2014-09-05Science
https://doi.org/10.1126/science.1255337