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RESEARCH PRODUCT
IC‐P‐024: Localization of hippocampal atrophy in Alzheimer's disease
Kaikai ShenKaikai ShenJurgen FrippFabrice MeriaudeauGaël ChetelatOlivier SalvadoPierrick Bourgeatsubject
EpidemiologyHealth PolicySubiculumDiseaseBiologyHippocampal formationmedicine.diseaseHippocampal atrophyNeuron lossPsychiatry and Mental healthCellular and Molecular NeuroscienceAtrophynervous systemDevelopmental NeurosciencemedicineNeurology (clinical)Geriatrics and GerontologyNeuroscienceShape analysis (digital geometry)description
The hippocampus presents the highest rate of atrophy in the early stage of Alzheimer's disease (AD), with more pronounced neuron loss reported in CA1 and subiculum. The aim of this study is to increase the discrimination power of hippocampal shape analysis between AD and normal controls (NC) by focusing on the subregions with atrophy associated with AD and describing the localized shape changes using statistical shape models (SSMs).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-07-01 | Alzheimer's & Dementia |